Mechanistic insight into immune amnesia and immunity induced by wild-type measles virus compared to live-attenuated measles vaccine
نویسندگان
چکیده
Abstract Despite the availability of a safe and effective vaccine, measles still causes significant mortality morbidity among children in developing countries. As disease that induces immune amnesia with increased susceptibility to other infections but also life-long immunity measles, little is known about immunogenetics B cells elicit measles-specific antibodies (Abs) natural infection vs vaccination. We therefore conducted single-cell RNA sequencing (scRNA-seq) longitudinal peripheral blood mononuclear (PBMC) lymph node (LN) samples from wild-type (WT) virus (MeV) live-attenuated vaccine (LAMV)-infected rhesus macaques (RMs) characterized their gene expression, cell repertoires clonotype changes via bioinformatic pipelines. Preliminary analysis two RMs across four timepoints (one WT MeV- one LAMV-infected RM) revealed similarities differences populations repertoires, providing important mechanistic insights into clonal development as compared Supported by grants NIH R01 AI153140 Jeffrey Richardson Fellowship
منابع مشابه
Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran
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Abbreviations: MMR: Measles, Mumps and Rubella; WHO: World Health Organization; SSPE: Subacute Sclerosing Panencephalitis; PAHO: Pan American Health Organization; CRS: Congenital Rubella Syndrome; MR: Measles-Rubella; GSK: GlaxoSmithKline; EZ: Edmonston Zagreb; CEF: Chicken Embryo Fibroblast; IBD: Inflammatory Bowel Disease; CDC: Centers for Disease Control and Prevention; SSPE: Subacute Sclero...
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.59.11